Cupramine effectively eradicates ectoparasite of both freshwater and marine fish. It has all the advantages of copper sulfate and chelated copper, but not the disadvantages. Like copper sulfate, it is fully ionic and effective at low concentrations. The cupric (Cu+2) charge is fully active. Like chelates, it is safe for fish and it is not precipitated in the filter bed. Unlike both, there is more than a 4x concentration gap between the minimal therpeutic dose and the toxic dose. Unlike copper salts, it is stable in the aquarium, and, unlike chelates, it is easily removed by chemical filtration. Unlike other copper products, it is both highly effective and safe in freshwater as well as marine water. It does not damage the filter bed. Cupramineā¢ contains 10,000 mg/L of copper and 100 mL treats over 500 gallons. Do not use in conjuction with ParaGuardā¢.